Innovators in Argonne’s entrepreneurship program amass millions in investments to aid their energy startups


The Chain Reaction Innovations (CRI) program has an impact in moving energy tech to market. As its first cohort of innovators graduates, CRI startups have raised more than $12.5 million in funding.

Energy demand is growing, and along with it, the need for innovation.

But bringing new innovations to the energy industry can be a long and arduous endeavor, especially for those just starting out. Chain Reaction Innovations (CRI), the entrepreneurship program at the U.S. Department of Energy’s (DOE’s) Argonne National Laboratory that is supported by the Advanced Manufacturing Office within DOE’s Office of Energy Efficiency and Renewable Energy, has found a more efficient way to accelerate the path to commercialization — and it has the numbers to prove it.

This summer, with the first four startups graduating from the program, CRI innovators have raised about $12.4 million in funding as of Aug. 12019. Out of that total, more than $5 million has come from private equity sources, and the rest has some from various organizations — including DOE — that offer open funding opportunities.

In addition to raising funds, CRI innovators have garnered major accolades for their work from leading organizations like NASA, the National Science Foundation, and DOE. They have also created more than 60 new jobs as their companies have grown and have established two dozen industrial collaborations across their respective industries.

The success of the first cohort is early validation that CRI is doing just what it is designed to do – accelerate the development of energy innovations and drive economic outcomes that improve sustainability for the U.S. and the world.

That’s the fundamental value of this program, to help the technology mature fast so that in two years the private sector is not funding fundamental science but instead taking proven technology, vetted by customers and the business world, to build companies, teams and manufacturing processes to deliver that product at-scale to customers.” — John Carlisle, Director, Chain Reaction Innovations

The primary metric we look at as a measure of our success is how much money the innovators raise through public and private sources through the course of the program. That number should surpass $10 million for each cohort we bring in, and we’ve well surpassed that with our first cohort,” said CRI Director John Carlisle. ​If we can replicate their magnitude of success in every cohort, over time, the program should easily deliver hundreds of millions of dollars in business value, as well as create hundreds of jobs in just a few years.”

How It Works

The program’s success lies in its unique design. CRI was intentionally created to do what most stakeholders in the private sector don’t: give initial support to early-stage, high-risk technologies to attract follow-on funding.

Funded by DOE’s Advanced Manufacturing Office and Argonne National Laboratory, support is offered in three ways. One is through access to the full range of capabilities a national laboratory has to offer. At Argonne, this includes access to world-class equipment and laboratory space, as well as more than 1,600 Ph.D. scientists, including manufacturing and energy experts. Innovators also receive financial support to develop and test their technologies and pursue additional funding opportunities.

Finally, innovators are mentored not only by laboratory experts but also collaborators outside the lab, including business and industry leaders at the University of Chicago’s Polsky Center for Entrepreneurship and Innovation and within Chicagoland’s rich energy ecosystem.

With resources already in place, they can mature their technologies more rapidly, and less expensively than in the outside world,” Carlisle said. ​That’s the fundamental value of this program, to help the technology mature fast so that in two years the private sector is not funding fundamental science but instead taking proven technology, vetted by customers and the business world, to build companies, teams and manufacturing processes to deliver that product at-scale to customers.”

The Impact

The success of Emergy Foods, an innovative company focused on sustainable, plant-based protein, exemplifies how CRI is succeeding in helping promote high-impact sustainable technology innovation in the United States.

Animal products (meat, fish, milk and eggs) are major dietary sources of protein, but animal farming is a major contributor to greenhouse gas emissions. As such, reducing the amount of animal products we eat (particularly beef) and increasing the efficiency of agricultural practices are important goals, both in reducing the demand on U.S. energy resources and also in reducing our carbon footprint.

Emergy’s journey through CRI demonstrates the obstacles energy innovators face when they try to mature their technologies to solve real-world problems. Thanks to the unique combination of support from Argonne, the Polsky Center and several others, Emergy leadership and CRI innovators Tyler Huggins and Justin Whiteley pivoted the focus of their technology multiple times, ultimately addressing a significant challenge in the world today: providing a sustainable source of protein.

This summer the company closed on $4.8 million in private funding and are currently building a pilot production facility in Boulder, Colo.

To build that much business value in such a short period of time around a hard tech with high impact that also creates jobs is truly impressive,” Carlisle said.  ​I don’t know any other lab-based program that’s done that.”

Another successful member of the first cohort is ClearFlame Engines, a company founded by Stanford University graduates Julie Blumreiter and BJ Johnson. The company offers a high-efficiency alternative fuel solution for heavy-duty engines and minimizes emissions that impact air quality. Since participating in CRI, Blumreiter and Johnson have received multiple Small Business Innovation Research grants, valued at over $1 million in total. Of that total, $355,000 will be used at Argonne to continue advancing their technology. The founders were also named 2019 Climate Fellows by Echoing Green.

Felipe Gomez del Campo is another member of the graduating cohort who has found success with CRI support. Through his company, FGC Plasma Solutions, Gomez del Campo has developed a unique fuel injector technology that uses plasma — a state of matter — to improve the efficiency of jet engines and gas turbines.

In two years, Gomez del Campo has garnered multiple awards for his innovation and sources of funding to develop it further. Through the course of the CRI program and since graduation, FGC Plasma has raised $3.6 million in additional funding and has plans to continue research and development at the Massachusetts Institute of Technology.

CRI is a fantastic program that serves a really important need,” Gomez del Campo said. ​It does a good job of putting the needs of entrepreneurs together with a readily-available solution, using all the excess space, brain power and capacity national labs have.”

The Future

Looking ahead, the future for CRI remains bright, Carlisle said. Eleven innovators are currently participating in CRI Cohorts 2 and 3, and a number of them have already found early success in raising funds for added research.

Erica Boeing is one example. As the founder of Accelerate Wind, she is pioneering an innovative approach for capturing wind energy at the edge of commercial rooftops. Only a year into the CRI program, Boeing already has surpassed several major milestones, including receiving a $225,000 Phase I grant from the National Science Foundation’s Small Business Technology Transfer Program.

Boeing and other members of Cohort 2 are preparing to showcase their achievements to investors during CRI’s annual Demo Day event. This year’s event will be held on Sept. 17 at the University of Chicago’s Gleacher Center in downtown Chicago.

There’s proof in success of the first cohort that our approach to accelerating innovation does work and can create a lot of business value in a short period of time,” Carlisle said. ​Seeing their success and the early successes of our second cohort gives us a lot to look forward to in the future.”

Chain Reaction Innovations provides innovators with the laboratory tools, seed capital, and collaborators needed to grow their early-stage technologies to enable them to attract the long-term capital and commercial partners needed to scale and launch into the marketplace. CRI is part of the Lab-Embedded Entrepreneurship Programs from the U.S. Department of Energy’s Office of Energy Efficiency and Renewable Energy (EERE). EERE created the Lab-Embedded Entrepreneurship Programs to provide an institutional home for innovative postdoctoral researchers to build their research into products and train to be entrepreneurs. The two-year program for each innovator is funded by EERE’s Advanced Manufacturing Office (AMO).

The Office of Energy Efficiency and Renewable Energy supports early-stage research and development of energy efficiency and renewable energy technologies to strengthen U.S. economic growth, energy security, and environmental quality.

Argonne National Laboratory seeks solutions to pressing national problems in science and technology. The nation’s first national laboratory, Argonne conducts leading-edge basic and applied scientific research in virtually every scientific discipline. Argonne researchers work closely with researchers from hundreds of companies, universities, and federal, state and municipal agencies to help them solve their specific problems, advance America’s scientific leadership and prepare the nation for a better future. With employees from more than 60 nations, Argonne is managed by UChicago Argonne, LLC for the U.S. Department of Energy’s Office of Science.

The U.S. Department of Energy’s Office of Science is the single largest supporter of basic research in the physical sciences in the United States and is working to address some of the most pressing challenges of our time. For more information, visit https://​ener​gy​.gov/​s​c​ience.

Latest News

See All
  • Semi-finalists Chosen for CRI's Cohort 8

    Twenty-eight individuals with a wide range of startup technologies were chosen to advance to the semi-finals and compete to join Chain Reaction Innovations’ (CRI) Cohort 8. A broad range of innovations are represented in this year’s applicants, including energy generation and distribution, bioremediation, anti-fouling, mineralization,… Read More

  • Chain Reaction Innovations wins a 2023 Chicago Innovation Award

    Chain Reaction Innovations has been recognized for solving unmet needs, creating jobs and generating new funding in the Chicago metro area. Chain Reaction Innovations, the entrepreneurship program at Argonne National Laboratory, has been recognized with a Chicago Innovation Award. (Image by Chicago Innovation.) Chain… Read More

  • Entrepreneurship program at Argonne opens applications for startups

    Chain Reaction Innovations seeks innovators to join Cohort 8 OCTOBER 26, 2023 Develop your clean energy or climate technology with the support of Argonne National Laboratory’s Chain Reaction Innovations program. Application deadline is 5 p.m. CST, Nov. 30.   Through Chain Reaction Innovations, early-stage… Read More

  • New startups Join Argonne’s Entrepreneurship Program

    Chain Reaction Innovations announces new cohort Clean energy startups embed at Argonne to develop innovative technologies that hold promise for helping mitigate climate change. Four startups joined Chain Reaction Innovations, the entrepreneurship program at Argonne, to develop clean-energy technologies over two years. Four new… Read More

  • Demo Day Showcased Innovators at Four National Labs

    Argonne hosted Demo Day in downtown Chicago, an event celebrating innovation at four laboratory-embedded entrepreneurship programs. Resilience of innovators recognized at gathering of national lab-based technology incubators. Getting an invention or new breakthrough from the laboratory into the broader world requires more than just a… Read More